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In article number 1805697, Xubo Yuan, Yunfeng Lu, Chunsheng Kang, and co‐workers report a platform technology that enables effective delivery of therapeutic monoclonal antibody (mAb) to the central nervous system (CNS) for brain‐tumor therapy. This is achieved by encapsulating the mAbs within nanocapsules that contain choline and acetylcholine analogues. The brain takes up these mAb nanocapsuels,...
As an essential component of immunotherapy, monoclonal antibodies (mAbs) have emerged as a class of powerful therapeutics for treatment of a broad range of diseases. For central nervous system (CNS) diseases, however, the efficacy remains limited due to their inability to enter the CNS. A platform technology is reported here that enables effective delivery of mAbs to the CNS for brain tumor therapy...
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