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In article number 1801198, Wen‐fei Dong, Kam W. Leong, and co‐workers report the development of an efficient protein‐delivery system comprising new biodegradable diselenide‐bridged mesoporous silica nanoparticles (MSNs) cloaked with cancer‐cell‐derived membrane fragments. The MSNs show oxidative and redox dual‐responsive matrix‐degradation behavior for controlled release of RNase A. They also exhibit...
Controlled delivery of protein therapeutics remains a challenge. Here, the inclusion of diselenide‐bond‐containing organosilica moieties into the framework of silica to fabricate biodegradable mesoporous silica nanoparticles (MSNs) with oxidative and redox dual‐responsiveness is reported. These diselenide‐bridged MSNs can encapsulate cytotoxic RNase A into the 8–10 nm internal pores via electrostatic...
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