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Expansion of a stem‐like subpopulation with increased growth and survival potential is thought to drive colorectal tumor growth and progression. We investigated a CD44‐positive (CD44(+)) subpopulation with extended growth and survival capacity in the human colon adenoma cell line LT97. This subpopulation expressed elevated levels of fibroblast growth factor 18 (FGF18) and fibroblast growth factor...
Fibroblast growth factor receptors (FGFRs) are important in malignant progression of several human epithelial tumors. However, little is known about FGFRs in canine or human soft tissue sarcomas. Thus, our aim was to investigate expression of FGFRs and their involvement in cell survival in sarcomas of both species. FGFR1–4 and FGFRL1 transcripts as well as IIIb/IIIc splice variants of FGFR1–3 were...
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