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This report investigates acute changes in the sensitivity of 5-HT 1A receptors in dorsal raphe (dr) neurons in response to elevated serotonin. DR neurons were isolated from adult rats and measurements of inhibition of Ca 2+ current by 5-HT were obtained using the whole cell patch clamp technique. During a 10-min application of 5-HT (with normal [Ca 2+ ] i ∼100 nM) a...
Introduction of GTP-γ-S into a neuronal cell spontaneously results in G-protein activation. A possible contribution to this mechanism is that some receptors have a constitutive activity that stimulates GDP/GTP exchange resulting in increased GTPase activity of G-protein α subunits, leading to a facilitation of GTP-γ-S binding. It follows that partial or complete uncoupling of receptors and G-proteins...
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