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Heavy metal ions and those of aluminum may interact with amyloid-β peptides (Αβ) associated with Alzheimer’s disease, contributing to Aβ aggregation and fibrillation that worsen this neuropathology. Nevertheless, the precise residues involved in metal ligation or interaction are yet to be established, although the N-terminal Aβ(1–16) peptide fragment is considered to be the metal-binding domain. However,...
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