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Metformin reduces cancer incidence and improves overall survival in diabetic patients. In preclinical studies, metformin decreases endometrial cancer (EC) cell growth by activation of AMPK/mTOR inhibition. We sought to determine the effects of metformin on serum/tumor biomarkers in women with EC.In this prospective trial, newly diagnosed EC patients underwent pre-treatment blood draw/endometrial biopsy,...
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