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We report on development and use of dynamic-clamp technology to understand how synchronous neuronal activity is generated in the hippocampus and entorhinal cortex. We find that “hard” real-time dynamic-clamp systems, characterized by very small maximal errors in timing of feedback, are necessary for cases in which fast voltage-gated channels are being mimicked in experiments. Using a hard real-time...
Reliable two-way communication with the nervous system is one of the biggest challenges in the field of neural engineering. Many problems have prevented us to achieve this goal mostly involving the mechanical, biological and electrical interface between neural tissue and the man-made electrodes. Significant results have been achieved to interface with the brain directly and the current research is...
Power Supply Controls are being developed at Oak Ridge National Laboratory (ORNL) to test transmission line components of the Electron Cyclotron Heating (ECH) system, with a focus on gyrotrons and waveguides, in support of the International Thermonuclear Experimental Reactor (ITER). The control is performed by several Programmable Logic Controllers (PLC's) located near the different equipment. A technique...
Each month, another large pile of electrophysiological papers is published, adding to the mountain of information that each of us in the community is expected to absorb and apply. Often, it is difficult to ascribe a causal role to these electrophysiological phenomena. Computational models are a common method for attempting to establish causality, but the immense complexity of neurons and neural circuits...
Heart rate variability has been used as a non-invasive index of parasympathetic activity as well as a possible predictor of mortality and sudden cardiac death. The purpose of this study was to investigate the relationship between patterns of heart rate variability associated with respiratory sinus arrhythmia (RSA), respiratory dysfunction and primary CHD risk factors which together may be used as...
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