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Myotoxins are abundant components of snake venoms, being a significant public health problem worldwide. Among them, Lys49 phospholipase A 2 homologue myotoxins cause extensive necrosis in skeletal muscle tissue. Their mechanisms of action are still poorly understood, but there is evidence that the C-terminal region is involved in membrane damage leading to myotoxicity. To investigate the effect...
A short peptide derived from the C-terminal region of Bothrops asper myotoxin II, a Lys49 phospholipase A 2 (PLA 2 ), was previously found to reproduce the bactericidal activity of its parent molecule. In this study, a panel of eight PLA 2 myotoxins purified from crotalid snake venoms, including both Lys49 and Asp49-type isoforms, were all found to express bactericidal activity,...
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