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Multitarget‐directed ligands (MTDLs) have recently attracted significant interest due to their superior effectiveness in multifactorial Alzheimer's disease (AD). Combined inhibition of two important AD targets, glycogen synthase kinase‐3β (GSK‐3β) and dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A), may be a breakthrough in the treatment of AD. Based on our previous work, we...