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Rationale Recent experimental data suggest that metabotropic glutamate receptor (mGluR) antagonists with selectivity for mGluR1 and mGluR2/3 enhance morphine-induced antinociception. Objectives The present study addressed the hypothesis that mGluR antagonists enhance opioid antinociception by increasing opioid efficacy. Materials and methods The antinociceptive effects of the partial μ-opioid...
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