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Protein biomarkers often exist as degradation fragments in biological samples, and affinity agents derived using a purified protein may not recognize them, limiting their value for clinical diagnosis. Herein, we present a method to overcome this issue, by selecting aptamers against a degraded form of the toxin B protein, which is a marker for diagnosing toxigenic Clostridium difficile infections....
Ein DNA‐Aptamer , das auf natürlich abgebaute Proteinfragmente abzielt, wurde von M. Liu, J. D. Brennan, Y. Li und Mitarbeitern selektiert (siehe die Zuschrift auf S. 7780). Das Aptamer bindet eine abgebaute Form von Toxin B aus Clostridium difficile und kann dieses Proteinfragment im Stuhl nachweisen. Die Methode ermöglicht die Entdeckung von DNA‐Aptameren, die durch Verwendung aufgereinigter Proteine...
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