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The molecular mechanism underlying how hypertension with increased norepinephrine (NE) accelerates vascular remodeling is unknown. The present study examined the hypothesis that the additive effects of mechanical stretch stress (SS) and NE on vascular remodeling are mediated by α 1 -adrenergic receptors (α 1 -ARs).In vitro quiescent mouse vascular smooth muscle cells were cultivated...
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