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Tumor necrosis factor-α (TNF-α) is a cytokine considered to play a key role in β-cell destruction in insulin-dependent diabetes mellitus (IDDM). Serum thymic factor (Facteur thymique serique; FTS) is a nonapeptide thymus hormone known to inhibit IDDM in a mouse model. In this study, the effect of TNF-α on the murine pancreatic β-cell line MIN6 was examined. Cell shrinkage and detachment were seen...
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