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In a fraction of patients, chronic lymphocytic leukaemia (CLL) can transform to Richter syndrome (RS), usually a diffuse large B–cell lymphoma (DLBCL). We studied genome‐wide promoter DNA methylation in RS and clonally related CLL‐phases of transformed patients, alongside de novo DLBCL (of non‐germinal centre B type), untransformed‐CLL and normal B‐cells. The greatest differences in global DNA methylation...
Richter's syndrome (RS) represents the transformation of chronic lymphocytic leukaemia (CLL) to aggressive lymphoma and is mostly represented by diffuse large B‐cell lymphoma (DLBCL), with a post‐germinal centre (GC) phenotype, clonally related to the pre‐existing CLL. RS has a very poor prognosis and its pathogenetic mechanisms are poorly understood. In order to gain additional hints in RS pathogenesis,...
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