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Since it has been shown that point mutations in the S4-S5 loop of the Shaker K + channel may disrupt fast inactivation, we investigated the role of three conserved amino acids in IV/S4-S5 of the adult human muscle Na + channel (L1471, S1478, L1482). In contrast to the K + channel mutations, the analogous substitutions in the Na + channel (S1478A/C, L1482A) did not...
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