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A spatiotemporally controllable gene delivery carrier is developed using a polymer‐conjugated, single layered MoS2 nanocomposite by W. J. Kim and co‐workers on page 1184. When subjected to near infrared light, the photothermal effect of MoS2 induces the endosomal escape of nanocomposite, thereby transferring it into the cytosol. Subsequently, intracellular redox conditions release the polymers from...
Stimuli‐responsive gene delivery systems maximize therapeutic efficacy by controlling the cytosolic conveyance and rate of effective gene release. We present herein a hybrid nanocomposite composed of a 2D nanomaterial, MoS2, modified by attaching two polymers (polyethylenimine (PEI) and polyethylenglycol (PEG)) via disulfide bonds. This MoS2–PEI–PEG nanocomposite interacts with DNA by electrostatic...
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