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Accumulating evidence has indicated a large-scale regulatory network generated by 3′untranslated regions (3′UTRs) in cancer. The 3′UTRs act not only in cis but, most likely even more importantly, as trans regulators of gene expression, consequently leading to phenotypic alterations. Here, we found that ectopic expression of SNAI1 3′UTR induced migration and invasion of ovarian cancer cell line RMUG-L...
A better understanding on the regulatory interactions of microRNA (miRNA) target genes and transcription factor (TF) target genes in ovarian cancer may be conducive for developing early diagnosis strategy. Thus, gene expression data and miRNA expression data were downloaded from The Cancer Genome Atlas in this study. Differentially expressed genes and miRNAs were selected out with t test, and Gene...
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