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Die Erythromelalgie ist eine seltene Erkrankung. Sie kann assoziiert mit hämatoonkologischen Erkrankungen, nach Einnahme bestimmter Medikamente und Toxine, aber auch als eigenständiges Krankheitsbild, beispielsweise bei Mutationen im Natriumkanal NaV1.7, auftreten. Klinisch findet sich eine charakteristische Trias aus attackenartig auftretenden Brennschmerzen und Hautrötung im Bereich der distalen...
Exaggerated neurogenic inflammation has been recognized to be one reason for many CRPS symptoms. Since angiotensin-converting enzyme (ACE) is a key enzyme for the termination of neurogenic inflammation, it has been selected as a candidate gene for CRPS predisposition. A previous report of an insertion/deletion (I/D) polymorphism in intron 16 within the ACE gene implicated an increased risk to develop...
Complex regional pain syndrome (CRPS) is characterized by a variety of clinical features including spontaneous pain and hyperalgesia. Increased neuropeptide release from peripheral nociceptors has been suggested as a possible pathophysiologic mechanism triggering the combination of trophic changes, edema, vasodilatation and pain. In order to verify the increased neuropeptide release in CRPS, electrically...
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