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The beta amyloid (Aβ) protein is a key molecule in the pathogenesis of Alzheimer's disease (AD). The tendency of the Aβ peptide to aggregate, its reported neurotoxicity, and genetic linkage studies, have led to a hypothesis of AD pathogenesis that many AD researchers term the amyloid cascade hypothesis. In this hypothesis, an increased production of Aβ results in neurodegeneration and ultimately dementia...
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