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The aim of this study was to determine the frequency and potential relevance of the promoter polymorphisms of the tumor necrosis factor-alpha (TNF-α) in the severity of rheumatoid arthritis (RA) in Mexicans. HLA-DR and polymorphisms at positions −238 and −308 of TNF-α gene were determined in 137 Mexican RA patients (44 with severe and 93 with non-severe RA) as well as in 169 healthy controls (99 were...
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