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Lens epithelium-derived growth factor (LEDGF) enhances the survival and growth of cells. To understand LEDGFs spatial localization and its putative function(s) during proliferation and differentiation, we localized LEDGF during terminal differentiation in whole rat lenses, lens epithelial cell (LEC) explants stimulated with FGF-2, and insulin, iris, human LECs with lentoids. In addition, intracellular...
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