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The effect of the muscarinic antagonist atropine on associative long-term potentiation (aLTP) of the CA1 population EPSPs was studied in rat hippocampal slices. Local application of atropine (10 -4 M) significantly suppressed aLTP in a weak radiatum input, measured 40-60 min after the tetanization (128 ± 10% vs. 168 ± 9% during control, P < 0.03) provided that a strong supporting...
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