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Leptin, or OB protein, is produced by fat cells and may regulate body weight by acting on the brain. To reach the brain, circulating leptin must cross the blood-brain barrier (BBB). Intravenously injected radioiodinated leptin ( 125 I-leptin) had an influx constant (K i ) into brain of (5.87)10 -4 ml/g-min, a rate 20 times greater than that of labeled albumin...
The penetration of four radioiodinated materials--Tyr-MIF-1, DAMGO, tyrosine, and albumin--into the periventricular tissue after ICV injection was studied in rats by film autoradiography. Rates of disappearance from the CNS for the injected compounds were also determined by computer-assisted image analysis of the autoradiographic images. The four materials showed distinct patterns of dispersion...
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