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Insulin detemir has a different profile of action on the central nervous system (CNS) than human insulin. It has been hypothesized that this is caused by an altered ability of insulin detemir to cross the blood–brain barrier (BBB). Here, we measured the permeability of the BBB to insulin detemir. We labeled insulin detemir with radioactive iodine (I-Det) and examined its ability to cross the BBB of...
Antibodies directed against amyloid beta protein (AßP) have been suggested to be effective in the treatment of Alzheimer's disease (AD). Here, we used in vivo and in vitro models to test some of the mechanisms by which antibodies may produce their effects. We found that the blood-to-brain uptake of murine AßP1–42 was significantly reduced when co-injected peripherally with an antibody known to reverse...
Banks, W. A., J. B. Jaspan and A. J. Kastin.Selective, physiological transport of insulin across the blood-brain barrier: Novel demonstration by species-specific radioimmunoassays.Peptides 18(8) 1257-1262; 1997.-Insulin in blood is thought to cross the blood-brain barrier (BBB) to act within the brain to help control appetite. We examined the ability of blood-borne insulin to cross the BBB. Human...
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