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This study examined the hydrodynamic performance of a multi-point absorber with a hydraulic power take-off (PTO) system and estimated the optimal conditions for maximum power extraction. The multi-point absorber is composed of two hemispheric buoys with a hydraulic PTO system. The hydrodynamic interactions between the two buoys were evaluated by modeling the buoys together with the PTO system. First,...
This paper reported the experimental demonstration of a radial preconcentrator/extractor in a micro/nanofluidic platform based on ion concentration polarization (ICP) phenomena. While various biomolecular preconcentration mechanisms have been developed for BioMEMS applications, an integration with downstream analyzer or an efficient recovery of concentrated sample still remain challenging. Here we...
Ion concentration polarization (ICP) phenomenon has been extensively researched for electro-desalination and purification applications because of its efficient capability of separating any charged species from brines. In this work, the ICP purifier, for the first time, was applied for a novel continuous peritoneal dialysate recycler. Most of charged hazardous substances were sufficiently removed by...
The aim of this study is to conduct a hydrodynamic analysis of a point absorber-type floating hemisphere with Power take-off(PTO) system for an optimum design of wave energy converter(WEC). In general, to predict the behavior of WEC, the equation of floating body motion can be solved in the frequency-domain analysis. A numerical model of PTO system is usually expressed as a linear damper-spring type...
This study presents an innovative design for a wave energy converter (WEC). The system is based on a novel mechanical power take-off (PTO) device that can absorb wave energy by converting the bidirectional motion of an ocean wave into the one-way rotation of an electric generator. First, the PTO mechanism and configuration are described in detail. A coupled mechanical and hydrodynamic time-domain...
This paper reported a rigorous experimental analysis of ion concentration distributions near a nanoporous membrane in a micro/nanofluidic platform. The distribution was highly polarized due to ion concentration polarization (ICP) phenomenon. While previous studies had reported most of co- and counter-ions were rejected from ICP layer, we showed that, for the first time, most of cations were transported...
We proposed a simple microfluidic device that enabled anisotropic absorption of detoxified S.typhimurium bacteria to microcubics so that the particles can swim toward desirable direction by chemotaxis of the bacteria. The speed of the “bacteria-based microrobot” was ∼5um/sec which is faster than any prior demonstrations, leading to an effective drug delivery system.
We proposed a simple microfluidic device that enabled anisotropic absorption of detoxified S. typhimurium bacteria to each microcubic so that the particles can swim toward desirable direction by chemotaxis of the bacteria. The speed of the “bacteria-based microrobot” was ∼5 um/sec which is faster than any prior demonstrations, leading to an effective drug delivery system.
This paper presents a method of fabricating pulverized drug, Lapatinib (Tykerb®), loaded micro chambers made of a biodegradable polymer, poly (ε-caprolactone) (PCL), for bacteria-based microrobots. The PCL is a biodegradable, biocompatible polymer which is approved by the U.S. Food and Drug Administration (FDA) for use in the implantable medical devices. Lapatinib is approved by the U.S. FDA for the...
Bacteria based biomedical micro-robot is being investigated or proposed to achieve effective and localized drug delivery system due to low toxicity and free of external power sources. In this work, we proposed a simple microfluidic system that enables anisotropic bacterial attachment to the drug containing micro chamber made of biodegradable polymer. A pin-ball type trapper can capture only one micro...
Bacteria-based biomedical microrobots have been proposed to achieve effective localized drug delivery. To enhance a directional locomotion of bacteria-attached microsystem, structures with selective bacterial adhesion are necessary. Having different surface morphologies of microstructures is beneficial for selective attachments of bacteria. In this paper, a surface energy modification method for controlling...
Micro-tapered long-period fiber gratings (MT-LPFGs) written in tapered fibers with different diameters of 125, 100, 75, and 50 μm are fabricated and their transmission characteristics with variations in strain and temperature are investigated.
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