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Downregulation of FKBP12.6 and sarcoplasmic reticulum Ca 2+ ATPase (SERCA2a) contributes to sudden cardiac death and heart failure. We aimed to test the hypothesis that (i) downregulation of FKBP12.6 and SERCA2a can be taken as molecular markers for drug interventions and (ii) such downregulation is produced by crosstalk between endothelin-reactive oxygen species and β-adrenoceptors stimulation,...
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