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BACKGROUNDTargeting tumor metabolism by energy restriction‐mimetic agents (ERMAs) has emerged as a strategy for cancer therapy/prevention. Evidence suggests a mechanistic link between ERMA‐mediated antitumor effects and epigenetic gene regulation.
METHODSMicroarray analysis showed that a novel thiazolidinedione‐derived ERMA, CG‐12, and glucose deprivation could suppress DNA methyltransferase (DNMT)1...
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