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Arginine-vasopressin (AVP) has been proposed to be an important mediator during chronic stress in the regulation of the hypothalamo-pituitary-adrenal axis. In the present study we addressed the role of AVP in maintaining adrenocortical responsiveness during chronic stress using the AVP deficient mutant Brattleboro rat. Heterozygous Brattleboro rats (di/+) served as controls and were compared to homozygous...
The effect of different α 2 -adrenoreceptor subtype agonists and antagonists on adrenocorticotrop hormone (ACTH) and β-endorphin release induced by ether stress was examined. Ether inhalation-induced ACTH and β-endorphin increase was inhibited by ICV administration of 30 μg but not 1 and 10 μg clonidine (α 2 -adrenoreceptor agonist). ICV oxymetazoline (α 2A -adrenoreceptor...
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