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Summary. Alzheimer’s Disease (AD) is the most common neurodegenerative disorder leading to dementia and its prevalence increases with age. The pathological features of AD are characterized by the β-amyloid protein (Aβ) deposits in the core of neuritic plaques and abnormal neurofibrillary tangles in the brain of AD patients. BACE1 is the major β-secretase to cleave the β-amyloid precursor protein (APP)...
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