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Purpose. Pharmacokinetics, metabolism and excretion of loteprednol etabonate (LE) were investigated in rats. Methods. The pharmacokinetic studies were performed by iv injections of LE (1-20 mg/ kg). In the metabolism and excretion studies, 0.5-10 mg/kg of LE were iv administered, bile and urine samples were collected for 6 hr. Results. The pharmacokinetic of LE showed a rapid, dose-dependent...
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