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Heterozygous familial hypercholesterolemia (heFH) is a common autosomal dominant hereditary disorder caused by mutations in the LDL-receptor gene that lead to elevated plasma levels of low-density lipoprotein-cholesterol (LDL-c). Robust lowering of LDL-c levels is essential for risk reduction of premature cardiovascular diseases and early death. European and Dutch guidelines recommend to treat LDL-c...
To determine the best lipid discriminant between atherosclerotic and normal coronary vessels in a community based cardiology clinic we measured fasting lipoproteins, apoA1 and apoB in 364 (M 287, F 77; age 65 ± 10) atherosclerotic coronary artery disease proven by angiography or previous myocardial infarction, intervention by PTCA or CABG; TIA, CVA or peripheral arterial disease) and in 123 controls...
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