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Bisphenol A (BPA) is used on a large scale in the manufacture of polycarbonate plastics. BPA has been shown to bind weakly to both estrogen receptor (ER) α and ER β. The objective of this study was to evaluate the effects of low-dose BPA on male sexual development after exposure at various stages of development. Mice of the estrogen-sensitive strain C57BL/6N were exposed to BPA orally at doses of...
The reproductive function in rats treated subcutaneously (s.c.) with 300 μg/g bisphenol A or 2 μg/g estradiol benzoate from postnatal Day 1 to 5 was examined after puberty as well as histolopathogic changes in reproductive organs. All male and female rats treated postnatally with estradiol benzoate showed poor reproductive capability, including adverse effects on masculine sexual behavior, and marked...
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