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With the arrival of the potent P2Y 12 antagonists, ticagrelor and prasugrel, the need for co-treatment with aspirin in acute coronary syndromes must be re-examined. This study assessed whether high-dose aspirin: a) provides additional anti-platelet efficacy, assessed in vivo and ex vivo, when combined with P2Y 12 inhibition; and/or b) has a negative effect on vascular function.Using...
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