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In article number 2101655, Kelong Fan, Zhanguo Li, Xiyun Yan, and co‐workers develop a highly sensitive platform for diagnosis of autoimmune disease. The antigen and anti‐Fc peptides are displayed on the surface of ferritin to construct nanocage‐based capture‐detection system. Multimeric display significantly enhances their binding ability to corresponding antibodies, thus improving the detection...
The detection of autoantibodies is critical for diagnosis of autoimmune diseases. However, the sensitivity is often limited by the properties of the antigens and the detection systems such as enzyme‐linked immunosorbent assay (ELISA). Here, employing the multidisplay ability of ferritin, a highly sensitive nanocage‐based capture‐detection system is designed, of which the sensitivity is 100–1000‐fold...
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