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In 37 patients with active rheumatoid arthritis (RA) responding insufficiently to a diseasemodifying anti-rheumatic drug (DMARD), we compared the safety and efficacy of methotrexate (MTX) used alone (MTX-only group) with MTX used in combination (combined-treatment group). Patients were assigned randomly to 5 years of treatment with MTX alone (initial dose, 7.5 mg/week) or with MTX (initial dose, 5...
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