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Methotrexate (MTX) was originally synthesised as an anti‐cancer drug. Soon it was also used in immunoinflammatory diseases, mainly in the field of rheumatology. However, the dose used in oncology is several‐fold higher as compared to the dose used in systemic immunoinflammatory rheumatological diseases. This led to the use of terms ‘low‐dose MTX’ (LD‐MTX) and ‘high‐dose MTX’ (HD‐MTX) respectively...
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