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The ability to expand genetic code in living cells has emerged as a powerful method with diverse applications. Here, we design replacement of the anticodons of E. coli tRNAs that recognize codons for 20 natural amino acids, with three anti‐stop codons, resulting in a total of 60 engineered tRNA constructs. We test these constructs one by one in E. coli, and found that six tRNAsCUA (tyrV, serX, hisR,...
Application of catalytic asymmetric hydrogenation of ethyl 2‐(benzo[b]thiophen‐5‐yl)‐2‐oxoacetate for the formal synthesis of cognitive enhancer T‐588 is described. The hydrogenation was conducted under the catalysis of Ru‐SunPhos system with HCl as additive. Ethyl 2‐(benzo[b]thiophen‐5‐yl)‐2‐hydroxy‐acetate was obtained with 98.6% ee, which could be easily upgraded to 99.5% ee after a simple recrystallization...
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