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Deep inspiration (DI) protects against methacholine-induced bronchoconstriction in healthy subjects. We hypothesized that this bronchoprotective effect of DI depends upon the inspiratory flow rate.Prospective, controlled study.Pulmonary function laboratory within a large tertiary medical center.Ten healthy nonsmokers without asthma or rhinitis.First, we performed a methacholine challenge in the absence...
Deep inspirations have the ability to dilate constricted airways. The impairment of this function has been associated with the occurrence of asthmatic symptoms. We evaluated whether the bronchodilatory effect of deep inspiration (DI) is affected by aging. We tested 25 healthy subjects (median age: 54 yrs, range: 25-83 yrs). Single dose methacholine (Mch) provocations were performed in the absence...
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