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To reduce genotyping costs, tagSNPs selection has gained lots of research interest and several algorithms have been proposed for LD tagSNPs selection. However, there is little understanding of benefits and drawbacks underlying the proposed approaches. In this paper, we broadly analyzed the existing algorithms for LD tagSNPs selection in a single population. It can be concluded that the original greedy...
Single Nucleotide Polymorphisms (SNPs) are widely used in Genome-wide Association Studies (GWAS). To reduce genotyping costs, several LD tagSNPs selection algorithms have been devised. In this paper, we proposed an improved hybrid algorithm HybridTag for LD tagSNPs selection. We first decomposed the genome into different precincts. For each precinct, we tried to use exhaustive search for tagSNPs selection...
Single Nucleotide Polymorphisms (SNPs) play an important role in Genome-wide Association Studies. To reduce genotyping costs, several LD tagSNPs selection algorithms have been proposed. In this paper, the advantages and disadvantages of current LD tagSNPs selection algorithms are analyzed. And a refined and heuristic algorithm HTag for LD tagSNPs selection is developed: (1) The tagSNPs selection procedure...
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