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Two regulatory genes, jadR2 and jadR3, in the jadomycin (jad) biosynthetic gene cluster of Streptomyces venezuelae encode homologues of γ‐butyrolactone receptor. JadR2 was previously shown to be a pseudo γ‐butyrolactone receptor. jadR3 is situated at the upstream of jadW123 encoding putative enzymes for γ‐butyrolactone biosynthesis. Disruption of jadR3 resulted in markedly decreased production of...
Jadomycin production is under complex regulation in Streptomyces venezuelae. Here, another cluster‐situated regulator, JadR*, was shown to negatively regulate jadomycin biosynthesis by binding to four upstream regions of jadY, jadR1, jadI and jadE in jad gene cluster respectively. The transcriptional levels of four target genes of JadR* increased significantly in ΔjadR*, confirming that these genes...
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