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Background Mean or maximal intima-media thickness (IMT) is commonly used as surrogate endpoint in intervention studies. However, the effect of normalization by surrounding or median IMT or by diameter is unknown. In addition, it is unclear whether IMT inhomogeneity is a useful predictor beyond common wall parameters like maximal wall thickness, either absolute or normalized to IMT or lumen size. We...
Cardiac Resynchronization Therapy (CRT) has emerged as an important therapy to improve pump function in heart failure patients with left bundle branch block (LBBB). Using a multi-scale modeling approach, we investigated the effect of mechano-electrical feedback (MEF) during LBBB and CRT on cardiac function and dispersion of repolarization. Our model describes cellular electrophysiology and calcium...
In this simulation study, we hypothesize that transmural heterogeneity in ion channel properties serves to homogenize cardiac workload. Mechanics and electrophysiology were modeled both on cellular and tissue level. Endo-, midmyo- and epicardial cells differed in ion channel properties only. A preload-afterload experiment was simulated to analyze cardiac pump function during normal conduction from...
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