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Objectives
Hepatitis B virus X (HBx) is closely associated with HBV‐related hepatocarcinogenesis via the inactivation of tumour suppressors. Protein phosphatase 2A (PP2A) regulatory subunit B56 gamma (B56γ), as a tumour suppressor, plays a critical role in regulating cellular phosphorylation signals via dephosphorylation of signalling proteins. However, the underlying mechanism that B56γ involved...
Objective
Aberrant activation of Wnt/β‐catenin signalling contributes significantly to the development of human colorectal cancers and β‐catenin is the key signalling molecule transducing canonical Wnt/β‐catenin signalling. Therefore, β‐catenin is a promising therapeutic target for cancer treatment. This study demonstrates that the oncogenic IKKε kinase phosphorylates β‐catenin to restrain its hyper...
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