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Oriented Dynamic Scaffolds
In article number 2305827, Huiming Wang, Yong He, Mengfei Yu, and co‐workers report a novel bioengineered strategy by a dynamic scaffold with temporary spacious micro‐grooved microtopography, persistent narrow micro‐grooved microtopography, and deformation force‐based mechanical stimuli, which can precisely spatiotemporally regulate neuronal proliferation, differentiation,...
Neurological function recovery after peripheral nerve injury (PNI) is exceptionally challenging, chiefly because neurons cannot efficiently proliferate, differentiate, and form regenerated axons to pass through the defect region expeditiously and transmit neurological signals. In this study, a four‐dimensional (4D) oriented dynamic scaffold is constructed based on shape memory polymer (SMP), which...