Search results for: Giuseppe Sanguineti

Items from 1 to 20 out of 86 results

article

Predictive classifier for intensive treatment of head and neck cancer

Kaveh Zakeri, Federico Rotolo, Benjamin Lacas, Lucas K. Vitzthum, more

Cancer > 126 > 24 > 5263 - 5273

Background This study was designed to test the hypothesis that the effectiveness of intensive treatment for locoregionally advanced head and neck cancer (LAHNC) depends on the proportion of patients' overall event risk attributable to cancer. Methods This study analyzed 22,339 patients with LAHNC treated in 81 randomized trials testing altered fractionation (AFX; Meta‐Analysis of Radiotherapy in...

article

Moderately accelerated intensity‐modulated radiation therapy using simultaneous integrated boost: Practical reasons or evidence‐based choice? A critical appraisal of literature

Francesca De Felice, Pierluigi Bonomo, Giuseppe Sanguineti, Ester Orlandi

Head & Neck > 42 > 11 > 3405 - 3414

Concurrent chemo‐radiotherapy is the non‐surgical mainstay of treatment for locally advanced head and neck squamous cell carcinoma (HNSCC). The following aspects have emerged as fundamental components of the combined approach: first, intensity modulated radiotherapy (IMRT) is the minimum standard technical requirement, with level 1 evidence in support of its reduction of late treatment‐induced morbidity...

article

Impact of BMI on HER2+ metastatic breast cancer patients treated with pertuzumab and/or trastuzumab emtansine. Real‐world evidence

Eriseld Krasniqi, Laura Pizzuti, Giacomo Barchiesi, Domenico Sergi, more

Journal of Cellular Physiology > 235 > 11 > 7900 - 7910

Body mass index (BMI) is a main indicator of obesity and its association with breast cancer is well established. However, little is known in the metastatic setting, especially in HER2‐positive patients. We assessed the influence of BMI on clinical outcomes of patients treated with pertuzumab and/or trastuzumab emtansine (T‐DM1) for HER2+ metastatic breast cancer (mBC). BMI was addressed as a categorical...

article

Distinct HR expression patterns significantly affect the clinical behavior of metastatic HER2+ breast cancer and degree of benefit from novel anti‐HER2 agents in the real world setting

Laura Pizzuti, Eriseld Krasniqi, Giacomo Barchiesi, Marina Della Giulia, more

International Journal of Cancer > 146 > 7 > 1917 - 1929

We analyzed data from 738 HER2‐positive metastatic breast cancer (mbc) patients treated with pertuzumab‐based regimens and/or T‐DM1 at 45 Italian centers. Outcomes were explored in relation to tumor subtype assessed by immunohistochemistry (IHC). The median progression‐free survival at first‐line (mPFS1) was 12 months. Pertuzumab as first‐line conferred longer mPFS1 compared to other first‐line treatments...

article

miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells

Mahrou Vahabi, Claudio Pulito, Andrea Sacconi, Sara Donzelli, more

Journal of Experimental & Clinical Cancer Research > 2019 > 38 > 1 > 1-16

Background Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer worldwide. They are typically characterized by a high incidence of local recurrence, which is the most common cause of death in HNSCC patients. TP53 is the most frequently mutated gene in HNSCC and patients carrying TP53 mutations are associated with a higher probability to develop local recurrence. MiRNAs, which...

article

Palbociclib plus endocrine therapy in HER2 negative, hormonal receptor‐positive, advanced breast cancer: A real‐world experience

Laura Pizzuti, Antonio Giordano, Andrea Michelotti, Marco Mazzotta, more

Journal of Cellular Physiology > 234 > 6 > 7708 - 7717

Data from 423 human epidermal growth factor receptor 2‐negative (HER2−), hormone receptor‐positive (HR+) advanced breast cancer (aBC) patients treated with palbociclib and endocrine therapy (ET) were provided by 35 Italian cancer centers and analyzed for treatment outcomes. Overall, 158 patients were treated in first line and 265 in second/later lines. We observed 19 complete responses and 112 partial...

article

Leukotoxicity after moderately Hypofractionated radiotherapy versus conventionally fractionated dose escalated radiotherapy for localized prostate Cancer: a secondary analysis from a randomized study

Giuseppe Sanguineti, Diana Giannarelli, Maria Grazia Petrongari, Stefano Arcangeli, more

Radiation Oncology > 2019 > 14 > 1 > 1-7

Background To compare WBC counts during treatment of localized prostate cancer with either conventionally fractionated (CF) or moderately hypofractionated (HYPO) radiotherapy. Methods Weekly blood test results were extracted from the charts of patients treated within a phase III study comparing HYPO to CF. In order to compare WBC counts at the same nominal dose in both arms and thus to tease out...

article

Impact of treatment expertise on the outcome of patients with head and neck cancer treated within 6 randomized trials

Paolo Bossi, Rosalba Miceli, Marco Benasso, Renzo Corvò, more

Head & Neck > 40 > 12 > 2648 - 2656

Background We evaluated the impact of center expertise, in terms of number of patients treated, on the overall survival (OS) and progression‐free survival (PFS) of patients with head and neck squamous cell carcinoma (SCC). Methods We performed a pooled analysis including data from 6 randomized trials in head and neck SCC conducted in Italy. We evaluated the association between OS or PFS and the...

article

Radiation-induced parotid changes in oropharyngeal cancer patients: the role of early functional imaging and patient−/treatment-related factors

Simona Marzi, Alessia Farneti, Antonello Vidiri, Francesca Di Giuliano, more

Radiation Oncology > 2018 > 13 > 1 > 1-10

Background Functional magnetic resonance imaging may provide several quantitative indices strictly related to distinctive tissue signatures with radiobiological relevance, such as tissue cellular density and vascular perfusion. The role of Intravoxel Incoherent Motion Diffusion Weighted Imaging (IVIM-DWI) and Dynamic Contrast-Enhanced (DCE) MRI in detecting/predicting radiation-induced volumetric...

article

Observational study of coagulation activation in early breast cancer: development of a prognostic model based on data from the real world setting

Chiara Mandoj, Laura Pizzuti, Domenico Sergi, Isabella Sperduti, more

Journal of Translational Medicine > 2018 > 16 > 1 > 1-9

Background Cancer and coagulation activation are tightly related. The extent to which factors related to both these pathologic conditions concur to patient prognosis intensely animates the inherent research areas. The study herein presented aimed to the development of a tool for the assessment and stratification of risk of death and disease recurrence in early breast cancer. Methods Between 2008...

article

Short course hypofractionated whole breast irradiation after conservative surgery: a single institution phase II study

Paola Pinnarò, Carolina Giordano, Alessia Farneti, Adriana Faiella, more

Journal of Experimental & Clinical Cancer Research > 2017 > 36 > 1 > 1-8

Background To assess the oncologic outcomes of hypofractionated whole breast irradiation (Hypo-WBI). Methods Eligible patients had undergone breast conservative surgery for early breast cancer (pTis-2) and none/limited nodal involvement. Hypo-WBI consisted of 34 Gy in 10 daily fractions over 2 weeks to the whole breast three-dimensional conformal radiotherapy (3DCRT), followed by a single fraction...

article

Neoadjuvant chemotherapy in triple‐negative breast cancer: A multicentric retrospective observational study in real‐life setting

Teresa Gamucci, Laura Pizzuti, Isabella Sperduti, Lucia Mentuccia, more

Journal of Cellular Physiology > 233 > 3 > 2313 - 2323

We aimed to assess the efficacy of neoadjuvant chemotherapy (NACT) in a cohort of 213 triple‐negative breast cancer (TNBC) patients treated in real‐world practice at eight Italian cancer centers. We computed descriptive statistics for all the variable of interest. Factors testing significant in univariate analysis were included in multivariate models. Survival data were compared by Kaplan–Meier curves...

article

Early prediction of radiotherapy-induced parotid shrinkage and toxicity based on CT radiomics and fuzzy classification

Marco Pota, Elisa Scalco, Giuseppe Sanguineti, Alessia Farneti, more

Artificial Intelligence in Medicine > 2017 > 81 > C > 41-53

Patients under radiotherapy for head-and-neck cancer often suffer of long-term xerostomia, and/or consistent shrinkage of parotid glands. In order to avoid these drawbacks, adaptive therapy can be planned for patients at risk, if the prediction is obtained timely, before or during the early phase of treatment. Artificial intelligence can address the problem, by learning from examples and building...

article

Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis

Benjamin Lacas, Jean Bourhis, Jens Overgaard, Qiang Zhang, more

The Lancet Oncology > 2017 > 18 > 9 > 1221-1237

The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over...

article

Double‐blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer

Laura Marucci, Alessia Farneti, Paolo Di Ridolfi, Paola Pinnaro, more

Head & Neck > 39 > 9 > 1761 - 1769

Background There is no widely accepted intervention in the prevention of acute mucositis during chemoradiotherapy for head and neck carcinoma. In the present double‐blind study, we tested 4 natural agents, propolis, aloe vera, calendula, and chamomile versus placebo. Methods Patients undergoing concomitant chemo‐intensity‐modulated radiotherapy (IMRT) were given natural agent or matched placebo;...

article

Patient-reported intestinal toxicity from whole pelvis intensity-modulated radiotherapy: First quantification of bowel dose–volume effects

Carla Sini, Barbara Noris Chiorda, Pietro Gabriele, Giuseppe Sanguineti, more

Radiotherapy and Oncology > 2017 > 124 > 2 > 296-301

Intestinal toxicity is commonly experienced during whole-pelvis intensity-modulated radiotherapy (WPRT) for prostate cancer. The aim of the current study was to assess bowel dose–volume relationships for acute patient-reported intestinal symptoms of patients treated with WPRT for prostate cancer.Complete data of 206 patients were available; the median dose to pelvic nodes was 51.8Gy (range 50.4–54...

article

The prediction of the treatment response of cervical nodes using intravoxel incoherent motion diffusion-weighted imaging

Simona Marzi, Francesca Piludu, Giuseppe Sanguineti, Laura Marucci, more

European Journal of Radiology > 2017 > 92 > C > 93-102

To investigate the predictive role of Intravoxel Incoherent Motion Diffusion-Weighted Imaging (IVIM-DWI) parameters on cervical nodal response to chemo-radiotherapy (CRT) of head and neck squamous cell carcinoma (HNSCC).Patients with pathologically confirmed HNSCC were included in the present prospective study, having at least one positive cervical lymph node (LN). They received concomitant CRT and...

article

Correlation study between intravoxel incoherent motion MRI and dynamic contrast-enhanced MRI in head and neck squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

Simona Marzi, Francesca Piludu, Chiara Forina, Giuseppe Sanguineti, more

Magnetic Resonance Imaging > 2017 > 37 > C > 1-8

To correlate intravoxel incoherent motion (IVIM) imaging and dynamic contrast-enhanced (DCE) MRI in head and neck squamous cell carcinoma (HNSCC).Forty untreated patients with HNSCC were included retrospectively in the study. Perfusion fraction f, diffusion coefficient D and perfusion-related diffusion coefficient D* were extracted by bi-exponential fitting of IVIM data. Semi-quantitative DCE-MRI...

article

Cross-institutional knowledge-based planning (KBP) implementation and its performance comparison to Auto-Planning Engine (APE)

Binbin Wu, Martijn Kusters, Martina Kunze-busch, Tim Dijkema, more

Radiotherapy and Oncology > 2017 > 123 > 1 > 57-62

To investigate (1) whether a plan library established at one institution can be applied for another institution’s knowledge-based planning (KBP); (2) the performance of cross-institutional KBP compared to Auto-Planning Engine (APE).Radboud University Medical Center (RUMC) provided 35 oropharyngeal cancer patients (68Gy to PTV⁶⁸ and 50.3Gy to PTV^50.3) with clinically-delivered and comparative APE plans...

article

Characterization of cervical lymph-nodes using a multi-parametric and multi-modal approach for an early prediction of tumor response to chemo-radiotherapy

Elisa Scalco, Simona Marzi, Giuseppe Sanguineti, Antonello Vidiri, more

Physica Medica > 2016 > 32 > 12 > 1672-1680

In the treatment of Head-and-Neck Squamous Cell Carcinoma (HNSCC), the early prediction of residual malignant lymph nodes (LNs) is currently required. Here, we investigated the potential of a multi-modal characterization (combination of CT, T2w-MRI and DW-MRI) at baseline and at mid-treatment, based on texture analysis (TA), for the early prediction of LNs response to chemo-radiotherapy (CRT).30 patients...

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Search results for: Giuseppe Sanguineti

Predictive classifier for intensive treatment of head and neck cancer

Moderately accelerated intensity‐modulated radiation therapy using simultaneous integrated boost: Practical reasons or evidence‐based choice? A critical appraisal of literature

Impact of BMI on HER2+ metastatic breast cancer patients treated with pertuzumab and/or trastuzumab emtansine. Real‐world evidence

Distinct HR expression patterns significantly affect the clinical behavior of metastatic HER2+ breast cancer and degree of benefit from novel anti‐HER2 agents in the real world setting

miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells

Palbociclib plus endocrine therapy in HER2 negative, hormonal receptor‐positive, advanced breast cancer: A real‐world experience

Leukotoxicity after moderately Hypofractionated radiotherapy versus conventionally fractionated dose escalated radiotherapy for localized prostate Cancer: a secondary analysis from a randomized study

Impact of treatment expertise on the outcome of patients with head and neck cancer treated within 6 randomized trials

Radiation-induced parotid changes in oropharyngeal cancer patients: the role of early functional imaging and patient−/treatment-related factors

Observational study of coagulation activation in early breast cancer: development of a prognostic model based on data from the real world setting

Short course hypofractionated whole breast irradiation after conservative surgery: a single institution phase II study

Neoadjuvant chemotherapy in triple‐negative breast cancer: A multicentric retrospective observational study in real‐life setting

Early prediction of radiotherapy-induced parotid shrinkage and toxicity based on CT radiomics and fuzzy classification

Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis

Double‐blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer

Patient-reported intestinal toxicity from whole pelvis intensity-modulated radiotherapy: First quantification of bowel dose–volume effects

The prediction of the treatment response of cervical nodes using intravoxel incoherent motion diffusion-weighted imaging

Correlation study between intravoxel incoherent motion MRI and dynamic contrast-enhanced MRI in head and neck squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

Cross-institutional knowledge-based planning (KBP) implementation and its performance comparison to Auto-Planning Engine (APE)

Characterization of cervical lymph-nodes using a multi-parametric and multi-modal approach for an early prediction of tumor response to chemo-radiotherapy

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