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IL-33, a recently discovered IL-1 family cytokine, is implicated in the development of T H 2-type responses in vivo. However, the cellular targets for IL-33 are poorly understood.We tested the hypotheses that dendritic cells (DCs) respond to IL-33 and that IL-33–activated DCs prime naive CD4 + T cells to produce T H 2-type cytokines.Dendritic cells were derived from mouse bone...
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