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Although the “3 beat rule” is widely utiized to discriminate patent foramen ovale (PFO)‐mediated right‐to‐left shunt (RTLS) from intrapulmonary RTLS using saline contrast transthoracic echocardiography (SCE), SCE diagnostic performance has yet to be validated using an invasive intracardiac standard. Percutaneous PFO occluder placement was recently shown to ameliorate hypoxia in patients with suspected...
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