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All three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are expressed in the human kidney, with ET-1 being the predominant isoform. ET-1 and ET-2 bind to two G-protein–coupled receptors, ET A and ET B , whereas at physiological concentrations ET-3 has little affinity for the ET A receptor. The human kidney is unusual among the peripheral organs in...
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