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The ectodomain of matrix protein 2 (M2e) of influenza virus is considered a rational target for a universal influenza A vaccine. To better understand M2e immune‐mediated protection, Fc receptor common γ chain deficient (FcRγ−/−) and wild‐type mice were immunized with a tandem repeat of M2e presented on virus‐like particles (M2e5x VLP). Levels of M2e‐specific antibodies that were induced in FcRγ−/−...
The generation of memory B cells by vaccination plays a critical role in maintaining antigen‐specific antibodies and producing antibody responses upon re‐exposure to a pathogen. B‐cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus‐like particle (VLP) vaccine in a transgenic mouse model that would identify germinal centre‐derived...
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