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Purpose Anitangiogenic and apoptotic properties of a novel chemically modified heparin derivative with low anticoagulant activity were evaluated on the experimental in vitro and in vivo model. Materials and Methods Heparin-lithocholate conjugate (HL) was initially synthesized by covalently bonding lithocholate to heparin. Folate-HL conjugate (FHL) was further synthesized by conjugating folate to...
Purpose Chemically modified heparin–DOCA was prepared and found to have markedly lower anticoagulant activity than heparin. In the present study, we elucidated the antiangiogenic and antitumoral activities of heparin–DOCA derivative. Methods To evaluate the antiangiogenic and antitumoral effects of heparin–DOCA, capillary-like tube formation assay, Matrigel plug assay in vivo, western blotting for...
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