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We have demonstrated previously that CD4 + CD25 + regulatory T cells (Treg) are important for spontaneous hepatic allograft tolerance. In this study, we examine the role of Treg in cardiac allograft acceptance induced by blockade of the CD40-CD40L pathway.A heterotopic heart transplant model of major histocompatibility complex–mismatched mice was performed. Expression of forkhead/winged...
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